ACTION OF AMPHOTERICIN B (FUNGIZONE) ON SPERMATOGENESIS IN THE RABBIT

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Abstract
Quantitative and qualitative analysis of the seminiferous epithelium of rabbits treated with Amphotericin B (Fungizone) revealed that ten intravenous injections of Fungizone, at a dose level of 2.0 mg Fungizone/kg body weight/ day, had no effect on the duration of the stages of the cycle of the seminiferous epithelium, but affected the spermatozoa prior to their release from the seminiferous tubules. Fungizone decreased the rate at which the spermatozoa migrated from the Sertoli cells towards the lumen. Thus, spermatozoa which normally are released prior to Stage 1 were retained in some Stage 1 tubules of injected animals. A single local injection of Fungizone, at a dose level of 0.2 mg/kg, into the cava vaginalis did not result in any observable change of the seminiferous epithelium. Unilateral castration had no effect on spermatogenesis in the remaining testis.