Effects of Testosterone and Dihydrotestosterone on FSH Serum Concentration and Follicular Growth in Female Rats

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Abstract
Intact mature female rats were injected once daily for 15 days with sesame oil, or with 100, 500 or 1,000 µg testosterone (T) or dihydrotestosterone (DHT). Both androgens, at 500 µg and 1,000 µg doses, produced ovarian atrophy. DHT was more effective in inducing anestrus, as well as uterine and vaginal atrophy. Mean diameters of all follicles with antra were reduced by DHT at 500 and 1,000 µg dose levels. In contrast, T did not suppress follicular growth, but actually, at the low dose (100 µg), significantly stimulated it. In a second series of experiments, in which the same treatments were given to ovariectomized rats, serum FSH was measured by radioimmunoassay 24 hr after the last injection. The low (100 µg) dose of DHT reduced serum FSH more markedly than the low dose of T did. At higher dose levels, both steroids reduced FSH serum levels to indistinguishably low values. These findings suggest that, in female rats, DHT suppresses FSH release more effectively than T. (Endocrinology95: 722, 1974)

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