Effect of Hypercapnia on CSF Turnover and Blood-CSF Barrier to Protein

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Abstract
Formation of cerebrospinal fluid (CSF) and transfer of albumin from blood to CSF was measured during steady state ventricular perfusion. In both normal and experimentally induced hydrocephalic cats elevation of arterial carbon dioxide pressure (Pco2) by 10% carbon dioxide (CO2) inhalation resulted in a decrease in absorption of CSF by approximately 50%. Under these conditions, there was no increase in CSF formation. The pH, PCO2and their changes in perfusate and CSF were similar and reflected those measured in blood. Hypercapnia caused more than an 11-fold increase in the influx of albumin into the perfusate of normal cats only. This effect was rapid and to a large extent reversible when the 10% CO2was removed from the breathing gas. The failure to detect a similar increase in permeability of the blood-CSF barrier to protein in hydrocephalic cats was attributed to the pathological changes in the choroid plexus due to the kaolin.

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