Synthetic (Asu1,7) eel calcitonin increases phosphorus content in the hepatic bile of intact and nephrectomized rats.

Publisher Website
Google Scholar
Abstract
The effect of synthetic [Asu1,7]eel calcitonin (CT) on P content in the hepatic bile was investigated in intact and nephrectomized rats. The s.c. administration of CT (80 mU/100 g body wt) produced a significant fall in the serum inorganic P concentration and a corresponding increase in the amount of P in the liver and kidney. These changes were observed even at the lowest dose of CT (40 mU/100 g body wt). The P contents in the spleen, heart, lungs and muscle were not significantly changed by CT administration. CT also provoked a marked elevation of P excretion into the bile. In nephrectomized rats, CT (80 mU/100 g body wt) caused a significant decrease in serum inorganic P concentration and a remarkable increase in liver P content. CT markedly increased P excretion into the bile of nephrectomized rats. These results support the theory that the hypophosphatemic effect of CT may be, at least partly, based on its action on liver in addition to kidney. This effect of CT on the liver may be the cause of increased excretion of P into the bile.