Effect of Length of Treatment with Bayer 2502 on Isolation of Trypanosoma cruzi and Resistance to Challenge in the Mouse *
- 1 May 1977
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 26 (3) , 382-386
- https://doi.org/10.4269/ajtmh.1977.26.382
Abstract
The effect of length of treatment of Trypanosoma cruzi with Bayer 2502 (Bay 2502, Lampit, Nifurtimox) on resistance to challenge and parasite isolation was studied in two experiments. In each, 200 mice were divided into groups of 20, infected with T. cruzi, and then treated with Bay 2502 for 1 to 8 consecutive weeks. Sixteen weeks after exposure, 10 mice from each experimental group were challenged with 150,000 trypomastigotes. The remainder were maintained for 8 more weeks and killed for isolation of parasites. Mice treated with Bay 2502 for up to 8 consecutive weeks were uniformly resistant to challenge, and parasites could not be isolated from groups treated for over 6 weeks. Results suggest that prolonged treatment with Bay 2502 eliminates T. cruzi from infected hosts and that resistance to challenge is not dependent on the presence of the organisms in mice.This publication has 1 reference indexed in Scilit:
- Chemotherapy and chemoprophylaxis of African trypanosomiasisExperimental Parasitology, 1962