An Efficient Synthesis of 3-Hydroxy-3-Trifluoromethyl Phthalide
- 1 December 1985
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 15 (14) , 1291-1297
- https://doi.org/10.1080/00397918508077277
Abstract
An efficient synthesis of 5 is described. Conversion of bromotoluene 1 to trifluoromethylacetophenone 2 followed by a benzylic oxidation-cyclization protocol afforded the target phthalide 5.Keywords
This publication has 2 references indexed in Scilit:
- Fluoro ketone inhibitors of hydrolytic enzymesBiochemistry, 1985
- Regiospecific synthesis of aromatic compounds via organometallic intermediates. 4. Synthesis of ortho-disubstituted benzenesThe Journal of Organic Chemistry, 1984