Twenty-four-hour blood pressure and heart rate profiles in humans. A twin study.
- 1 February 1994
- journal article
- abstracts
- Published by Wolters Kluwer Health in Hypertension
- Vol. 23 (2) , 244-253
- https://doi.org/10.1161/01.hyp.23.2.244
Abstract
To delineate the relative roles of genetic and environmental factors on physiological variations of blood pressure and heart rate, we performed 24-hour ambulatory blood pressure monitorings with simultaneous polygraphic sleep recordings in 28 monozygotic and 16 dizygotic healthy young male twin pairs investigated in a standardized physical and social environment. Blood pressure and heart rate were measured every 10 minutes for 24 hours. A best-fit curve based on the periodogram method was used to quantify changes in blood pressure and heart rate over the 24-hour span. Surprisingly, monozygotic twins as a group tended to have higher blood pressure values than dizygotic twins, and this difference reached the level of significance for daytime systolic blood pressure (P < .005). Although environmental influences largely controlled the mean levels and characteristics of the 24-hour systolic blood pressure variations, significant genetic effects were demonstrated for the mean levels and 24-hour patterns of diastolic blood pressure and heart rate. For both diastolic blood pressure and heart rate, the genetic effects concerned largely the same characteristics of the 24-hour profiles: the 24-hour mean, the daytime mean, the value of the evening acrophase, and the value of the major acrophase. Moreover, there was a strong genetic influence for the amplitude of the 24-hour rhythm of heart rate.Keywords
This publication has 22 references indexed in Scilit:
- Are there interactions and relations between genetic and environmental factors predisposing to high blood pressure?Hypertension, 1991
- Quantitative analysis of the 24-hour blood pressure and heart rate patterns in young men.Hypertension, 1991
- Genetic determinants of EEG sleep: a study in twins living apartElectroencephalography and Clinical Neurophysiology, 1991
- Inheritance of blood pressure and haemodynamic phenotypes measured at rest and during supine dynamic exerciseJournal Of Hypertension, 1991
- EEG sleep patterns in man: a twin studyElectroencephalography and Clinical Neurophysiology, 1989
- Dominance alone is not enoughBehavior Genetics, 1988
- A Sequence in M13 Phage Detects Hypervariable Minisatellites in Human and Animal DNAScience, 1987
- Blood pressure reactivity in adult male twins.Health Psychology, 1987
- Variability of heart rate, P-R, QRS and Q-T durations in twinsJournal of Electrocardiology, 1980
- Extension of Sample Sizes and Percentage Points for Significance Tests of Outlying ObservationsTechnometrics, 1972