Administration of two macrophage-derived interferon-γ-inducing factors (IL-12 and IL-15) induces a lethal systemic inflammatory response in mice that is dependent on natural killer cells but does not require interferon-γ
- 30 April 2002
- journal article
- research article
- Published by Elsevier in Cellular Immunology
- Vol. 216 (1-2) , 31-42
- https://doi.org/10.1016/s0008-8749(02)00501-4
Abstract
No abstract availableKeywords
This publication has 40 references indexed in Scilit:
- Elevated Plasma Concentrations of Interferon (IFN)–γ and the IFN‐γ–Inducing Cytokines Interleukin (IL)–18, IL‐12, and IL‐15 in Severe MelioidosisThe Journal of Infectious Diseases, 1999
- Signaling pathways activated by interferonsExperimental Hematology, 1999
- THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune ResponsesAnnual Review of Immunology, 1998
- The Regulation and Biological Activity of Interleukin 12Leukemia & Lymphoma, 1998
- CELLULAR RESPONSES TO INTERFERON-γAnnual Review of Immunology, 1997
- The Instructive Role of Innate Immunity in the Acquired Immune ResponseScience, 1996
- Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral DiseaseCell, 1996
- Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.The Journal of Experimental Medicine, 1995
- Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient miceNature, 1994
- Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ GenesScience, 1993