Influence of Submandibular Salivary Glands on Hormone Responsiveness of Mouse Mammary Glands
- 1 December 1987
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 186 (3) , 368-377
- https://doi.org/10.3181/00379727-186-42627
Abstract
Surgical removal of the submandibular salivary glands (sialoadenectomy) of female Balb/c mice significantly (P < 0.05) reduced mammary development as judged by development scores and mammae DNA levels. Reduction in mammae development score by sialoadenectomy was observed in both mice saline injected and mice treated with estradiol and progesterone. Autografts of submandibular salivary tissue or daily administration of EGF to sialoadenectomized mice partly alleviated the atrophy of the mammary gland induced by sialoadenectomy (P < 0.05). The results of our studies are consistent with a model of mammary gland developmental regulation that includes the submandibular salivary gland as a mediator of mammogenesis via secretion of EGF.This publication has 12 references indexed in Scilit:
- Thyroid Hormone Regulation of Epidermal Growth Factor Receptor Levels in Mouse Mammary GlandsEndocrinology, 1986
- Changes in epidermal growth factor concentrations of submandibular gland, plasma and urine of normal and sialoadenectomized female mice during various reproductive stagesJournal of Endocrinology, 1985
- Epidermal Growth Factor Receptor Levels in Mouse Mammary Glands in Various Physiological States*Endocrinology, 1985
- Hormonal modulation of mouse plasma concentration of epidermal growth factorActa Endocrinologica, 1984
- Evidence for physiological function of epidermal growth factor: pregestational sialoadenectomy of mice decreases milk production and increases offspring mortality during lactation period.Proceedings of the National Academy of Sciences, 1984
- Epidermal Growth Factor Stimulates Cell Proliferation and Inhibits Functional Differentiation of Mouse Mammary Epithelial Cells in Culture*Endocrinology, 1983
- Growth Factor- and Cyclic Nucleotide-Induced Proliferation of Normal and Malignant Mammary Epithelial Cells in Primary Culture*Endocrinology, 1980
- Serum concentrations of epidermal growth factor in human pregnancyAmerican Journal of Obstetrics and Gynecology, 1973
- PROPHYLAXIS OF SPONTANEOUSLY DEVELOPING MAMMARY-CARCINOMA IN C3H/HEJ FEMALE MICE BY SUPPRESSION OF PROLACTIN1973
- A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acidBiochemical Journal, 1956