Abstract
Last week, a vast National Heart, Lung, and Blood Institute study of hormone replacement therapy (HRT) came to a halt, and more than 16,000 participating women received a letter recommending that they stop taking their pills. The study, part of a huge research program called the Women's Health Initiative, stunned many supporters of HRT and led many women taking the drugs--some 6 million in the United States alone--to call their doctors for advice. But epidemiologists who have studied the issue for years say they're not so surprised.

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