Correlation of Serum Concentrations of Cystatin C and Creatinine to Inulin Clearance in Liver Cirrhosis
Open Access
- 1 May 2000
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 46 (5) , 712-715
- https://doi.org/10.1093/clinchem/46.5.712
Abstract
The gold standard for the evaluation of the glomerular filtration rate (GFR) is inulin clearance (CIn), but its widespread use is prevented by several technical difficulties ( 1). The most commonly used marker for GFR is serum creatinine. However, serum creatinine concentrations should be interpreted with caution as a filtration marker in liver cirrhosis because they do not adequately reflect renal dysfunction. Increased tubular secretion and muscle wasting account for the disparity between creatinine concentrations and GFR in cirrhotic patients ( 2)( 3)( 4). Thus, GFR has been demonstrated repeatedly to be overestimated by serum creatinine ( 1)( 2)( 3)( 4)( 5).Keywords
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