ACUTE NEUROPATHOLOGY IN SOMAN POISONED RATS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 5  (2) , 53-57
Abstract
Groups of rats received single s.c. injections of the highly toxic organophosphate compound, soman, at 106, 133 or 165 .mu.g/kg and were observed during the acute phase of intoxication. Survivors were killed at intervals up to 14 days after exposure, and brain sections were examined by light microscopy. A consistent pattern of neuronal degeneration and necrosis was observed in brains of animals which had experienced convulsions during the intoxication. The lesions had an appearance and distribution similar to that reported for hypoxic injury and status epilepticus. No lesions were observed in animals which did not experience convulsions. Soman, and possibly other similar organophosphate compounds, may have produced significant irreversible damage to the CNS.

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