The potential in biotechnology of immobilized cells and of immobilized multistep enzyme—coenzyme systems

Publisher Website
Google Scholar
Abstract
Despite the increasing number of reports in the literature on the immobilization of cells or enzymes for the production of more complex compounds involving multistep enzyme systems and coenzymes, no such systems are yet known to be used commercially on a large-scale basis (vaccine production by microcarrier-attached animal cells being an exception). Various systems that have been described are reviewed, including plant and animal cells. Special emphasis is given to the choice to be made between the use of immobilized cells or immobilized enzyme sequences. In this context alternative regeneration methods for coenzymes are discussed. Special attention is brought to the potential for such biosyntheses with immobilized-permeabilized cells. It is likely that the list of immobilized cells and enzymes used at present and restricted to single enzymic steps will be extended in the not too distant future by more complex systems.

This publication has 40 references indexed in Scilit: