Reduced high density lipoprotein in stroke: relationship with elevated triglyceride and hypertension

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Abstract
Lipids and lipoproteins were analyzed in 41 survivors of stroke, aged less than 65 yr, and the same number of age and sex matched controls without vascular disease. The stroke subjects had no evidence of coronary artery or peripheral vascular disease. High density lipoprotein [HDL] cholesterol was significantly lower (1.19 .+-. 0.06 mmol/1) in the stroke subjects than the controls (1.47 .+-. 0.07 mmol/1). Triglyceride was also elevated in stroke subjects, but was confined to those taking antihypertensive drugs which included .beta.-blockers and/or thiazide diuretics. The low levels of HDL in stroke were independent of hypertension or its treatment. Low levels of HDL appear to be associated with cerebrovascular disease, while elevated triglyceride is a complication of anti-hypertensive therapy.