Palladium-Catalyzed Cross-Coupling Reactions in Total Synthesis
Top Cited Papers
- 8 July 2005
- journal article
- review article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 44 (29) , 4442-4489
- https://doi.org/10.1002/anie.200500368
Abstract
In studying the evolution of organic chemistry and grasping its essence, one comes quickly to the conclusion that no other type of reaction plays as large a role in shaping this domain of science than carbon–carbon bond-forming reactions. The Grignard, Diels–Alder, and Wittig reactions are but three prominent examples of such processes, and are among those which have undeniably exercised decisive roles in the last century in the emergence of chemical synthesis as we know it today. In the last quarter of the 20th century, a new family of carbon–carbon bond-forming reactions based on transition-metal catalysts evolved as powerful tools in synthesis. Among them, the palladium-catalyzed cross-coupling reactions are the most prominent. In this Review, highlights of a number of selected syntheses are discussed. The examples chosen demonstrate the enormous power of these processes in the art of total synthesis and underscore their future potential in chemical synthesis.Keywords
This publication has 459 references indexed in Scilit:
- A Concise and Flexible Total Synthesis of (−)‐Diazonamide AAngewandte Chemie International Edition in English, 2003
- Stereospecific Total Synthesis of the Antiviral Agent Hamigeran B—Use of Large Silyl Groups to Enforce Facial Selectivity and to Suppress HydrogenolysisAngewandte Chemie International Edition in English, 2003
- The Second Total Synthesis of Diazonamide AAngewandte Chemie International Edition in English, 2003
- Enantioselective Total Synthesis of the Cyclophilin-Binding Immunosuppressive Agent Sanglifehrin AAngewandte Chemie, 2001
- Totalsynthese von Colombiasin AAngewandte Chemie, 2001
- The Synthesis of CP-263,114 and CP-225,917: Striking Long-Range Stereocontrol in the Fashioning of C7Angewandte Chemie, 2000
- The Chemistry and Biology of DiscodermolideChemBioChem, 2000
- Totalsynthese von Sanglifehrin AAngewandte Chemie, 1999
- Palladacyclen als effiziente Katalysatoren für ArylkupplungsreaktionenAngewandte Chemie, 1995
- Intramolekulare stöchiometrische (Li, Mg, Zn) und katalytische (Ni, Pd, Pt) Metallo‐En‐Reaktionen in der Organischen SyntheseAngewandte Chemie, 1989