Chemical Pathology of Acute Amino Acid Deficiencies

Publisher Website
Google Scholar
Abstract
Young Sprague-Dawley rats were force-fed for 3 days a purified diet devoid of threonine and containing 0.6, 5, or 25% corn oil. All animals developed fatty liver with a periportal distribution, increased hepatic glycogen, and atrophy of the pancreas, submaxillary gland, stomach, spleen and thymus. The results indicate that a decrease in dietary fat intake from 5 to 0.6% corn oil does not alter the pathologic changes due to the deficient diet. An increase in dietary fat intake from 5 to 25% corn oil did not protect against the pathologic changes, but actually accentuated some of the changes due to the deficient diet.