Feature of Internucleotidic 2′,3′-Cyclicphosphate Intermediates During Liquid and Solid Phase Synthesis of RNA Fragments and Practical Synthesis of Octaadenylate in the Phosphoramidite Approach
- 5 June 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 16 (6) , 1057-1060
- https://doi.org/10.1246/cl.1987.1057
Abstract
Internucleotidic cyclic phosphate intermediates were found to be hydrolyzed completely to give no 2′-5′ linkages under the usual conditions for deprotection in RNA synthesis.Keywords
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