A stereoselective synthesis of (−)-tetrahydrolipstatin
- 1 January 1999
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 1999 (17) , 1743-1744
- https://doi.org/10.1039/a904533c
Abstract
A stereoselective synthesis of (–)-tetrahydrolipstatin has been accomplished utilizing olefin metathesis of an acrylate ester as the key step.Keywords
This publication has 5 references indexed in Scilit:
- First Clinical Studies with Orlistat: A Short ReviewObesity Research, 1995
- The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipaseJournal of Biological Chemistry, 1991
- Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatinBiochemical Journal, 1988
- Studies on the antiobesity activity of tetrahydrolipstatin, a potent and selective inhibitor of pancreatic lipase.1987
- Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity.The Journal of Antibiotics, 1987