New gas‐chromatographic/mass spectrometric method for the quantitative analysis of primary aromatic amines in main‐ and side‐stream cigarette smoke. I

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Abstract
A sensitive and accurate method to quantitate 17 primary aromatic amines in tobacco smoke has been set up. two Italian commercial brands of cigarette were smoked in a home‐made smoking machine; the amines in the smoke were trapped in dilute hudrochloric acid (containing 2H5‐aniline, 13C1‐o‐toluidine and 2H9‐4‐aminobiphenyl as internal standards) and, after extraction and purification, derivatized as pentafluoropro‐pionamides and measured by gas chromatography/mass spectrometry in the selected‐ion‐monitoring mode. Our results confirmed that side‐stream smoke contains total levels of aromatic amines about 50–60 times higher than those of main‐stream smoke of black‐tobacco cigarettes is richer in aromatic amines compared to light‐tobacco cigarettes.