Emergence of a Pneumococcal Clone with Cephalosporin Resistance and Penicillin Susceptibility
Open Access
- 1 September 2001
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (9) , 2648-2650
- https://doi.org/10.1128/aac.45.9.2648-2650.2001
Abstract
We report two South African serotype 6B pneumococcal isolates with cephalosporin resistance, yet with susceptibility to penicillin. DNA fingerprinting revealed that they were clonal in origin. pbp 2X and 1A genes showed major alterations typical of cephalosporin-resistant pneumococci. The pbp 2B gene was completely unaltered, explaining the penicillin susceptibility of the isolates.Keywords
This publication has 15 references indexed in Scilit:
- Alterations in MurM, a Cell Wall Muropeptide Branching Enzyme, Increase High-Level Penicillin and Cephalosporin Resistance in Streptococcus pneumoniaeAntimicrobial Agents and Chemotherapy, 2001
- Differential subsequence conservation of interspersed repetitive Streptococcus pneumoniae BOX elements in diverse bacteria.Genome Research, 1995
- Genetics of high level penicillin resistance in clinical isolates ofStreptococcus pneumoniaeFEMS Microbiology Letters, 1995
- Mosaic pbpX genes of major clones of penicillin‐resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin‐sensitive Streptococcus oralisMolecular Microbiology, 1994
- Genetic diversity of penicillin-binding protein 2B and 2X genes from Streptococcus pneumoniae in South AfricaAntimicrobial Agents and Chemotherapy, 1993
- Genetics of resistance to third‐generation cephalosporins in clinical isolates of Streptococcus pneumoniaeMolecular Microbiology, 1992
- Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin‐resistant clinical isolates of Streptococcus pneumoniaeMolecular Microbiology, 1991
- Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.Proceedings of the National Academy of Sciences, 1989
- PENICILLIN-BINDING PROTEINS AND THE MECHANISM OF ACTION OF BETA-LACTAM ANTIBIOTICSAnnual Review of Biochemistry, 1983
- Penicillin-binding proteins of multiply antibiotic-resistant South African strains of Streptococcus pneumoniaeAntimicrobial Agents and Chemotherapy, 1980