Construction and Biological Characterization of an Infectious Molecular Clone of HIV Type 1GB8
- 10 August 2000
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 16 (12) , 1175-1178
- https://doi.org/10.1089/088922200415027
Abstract
Here we report the construction, sequencing, and repair of a molecular clone of HIV-1GB8, a virus representative of HIV-1 subtype B strains circulating in the UK. The phenotype of virus produced by the clone matches that of the parental virus. The molecular clone will be used in the production of attenuated virus stocks for chemical inactivation to allow development of faccines based on killed whole virus preparations.Keywords
This publication has 17 references indexed in Scilit:
- Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytesNature, 1999
- HIV-1 Tat: a polypeptide for all seasonsImmunology Today, 1998
- Multiple sequence alignment with Clustal XPublished by Elsevier ,1998
- Initial Studies on Active Immunization of HIV-Infected Subjects Using a gp120-Depleted HIV-1 Immunogen: Long-Term Follow-UpJAIDS Journal of Acquired Immune Deficiency Syndromes, 1996
- A multistep procedure for the chemical inactivation of human immunodeficiency virus for use as an experimental vaccineVaccine, 1995
- A molecular and serologic study of the envelope gene of the British isolate: HIV-1 GB8Vaccine, 1995
- Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and RecipientsScience, 1995
- The assembly of HIV within the Golgi apparatus and Golgi-derived vesicles of JM cell syncytiaAIDS, 1991
- Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patientJournal of Medical Virology, 1991