ECHOCARDIOGRAPHIC MEASUREMENTS OF HEMODYNAMIC-EFFECTS AND PHARMACOKINETICS OF PRENALTEROL

  • 1 January 1981
    • journal article
    • research article
    • Vol. 70  (5) , 394-398
Abstract
The dose-dependent hemodynamic effects and pharmacokinetics of parenteral prenalterol (0.5-10 .mu.g/kg per min), a new cardioselective .beta.-1-adrenoceptor agonist, were studied in 10 healthy human volunteers by computed echocardiography. Prenalterol induced a dose-dependent strong and persistent increase in contractility (FV (fiber shortening) 46%, .hivin.VCF (mean rate circumferential shortening) 60%, STI (systolic time interval) 12%), heart index (46%) and heart rate (27%) and a moderate, not significant, decrease in VED [end-diastolic volume] (14%). Afterload and mean arterial blood pressure were nearly unaltered. The hemodynamically effective threshold concentration of prenalterol in plasma was 20-30 nmol/l, the mean value of maximum concentration 493 nmol/l; 1 h after stopping the infusion prenalterol plasma level was .apprx. 90 nmol/l. A strong linear correlation between the hemodynamic alterations and the log of prenalterol plasma concentrations was not apparent.

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