CD4‐like molecules in human sperm
- 26 February 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 261 (2) , 339-342
- https://doi.org/10.1016/0014-5793(90)80586-8
Abstract
The expression of a molecule recognized by CD4 monoclonal antibodies was investigated on human sperm using immunolabelling, biochemical and immunochemical methods. Flow cytometry detected a significant fluorescence signal. SDS-PAGE analysis and Western blotting identified a molecule of 60 kDa, consistent with a CD4-like structure as confirmed after selective immunoseparation. Additional bands reacting with anti-CD4 were found in sperm extracts (73 kDa) and seminal fluid (90 kDa). These data indicate that sperm express a molecule similar to the receptor for HIV described on mononuclear cells.Keywords
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