Coxsackie A9 Virus: Mutation from Drug Dependence to Drug Independence

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Abstract
During the multiplication of Coxsackie A9 virus dependent on 2 - (α - hydroxybenzyl) - benzimidazole there arise some drug-independent virus particles, which are either drug-resistant or drug-sensitive. We studied the properties of such revertant particles under conditions which did not favor the selection of resistant over sensitive virus particles. These particles exhibited a wide range of responses to 2-(α-hydroxybenzyl)-benzimidazole, from high sensitivity to high resistance. Subclones showed the same degree of sensitivity or resistance as the respective parent clones.