Angiotensin II: dependence of hormone affinity on the electronegativity of a single side chain
- 1 March 1984
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 27 (3) , 315-320
- https://doi.org/10.1021/jm00369a015
Abstract
Structure-activity studies on rabbit aorta of angiotensin II anlaogs have suggested a possible relationship between the electronegativity of the aromatic side chain in position 4 (Tyr) and the observed affinity. To test this hypothesis, several other anlogs modified in position 4 were prepared, and all available analogs were tested in 3 bioassays: in vitro on rabbit aorta strip, in vivo on the rat blood pressure, and the the binding assay on beef adrenocortical membranes. In all 3 bioassays the postulated correlation confirmed that angiotensin II affinity depends inversely on the electronegativity of the aromatic side chain in position 4.This publication has 11 references indexed in Scilit:
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