Cerebral Blood Flow in the Rat
- 1 May 1958
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 193 (2) , 272-274
- https://doi.org/10.1152/ajplegacy.1958.193.2.272
Abstract
The cerebral uptake of iodoantipyrine (I131) was measured in anesthetized rats as a function of time after a single intravenous injection. The cerebral content stabilized in 7–9 seconds and remained constant for 64 seconds indicating that the brain and body had the same extraction ratio for the label. The cerebral blood flow fraction therefore corresponded to the fractional uptake of iodoantipyrine by the brain. The cerebral blood flow was calculated as the product of the cardiac output and the cerebral flow fraction. The perfusion rate of the brain was found to be 0.51 ml/gm/min. in female rats.Keywords
This publication has 3 references indexed in Scilit:
- Regional Blood Flow by Fractional Distribution of IndicatorsAmerican Journal of Physiology-Legacy Content, 1958
- Croonian Lecture - The active and passive exchanges of inorganic ions through the surfaces of living cells and through living membranes generallyProceedings of the Royal Society of London. B. Biological Sciences, 1946
- THE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN BY THE USE OF NITROUS OXIDE IN LOW CONCENTRATIONSAmerican Journal of Physiology-Legacy Content, 1945