Laboratory studies with the systemic trichononacide, metronidazole

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Abstract
Laboratory studies with the trichomonacidal agent, metronidazole, show that 66 strains ofT. vaginaliswere killed in three days by concentrations of 0·0625 μg./ml. to 1 μg./ml.Estimations of serum and urine levels in nine volunteers, the serum levels in 31 women, and the urine levels in 33 women show that metronidazole is rapidly absorbed and excreted in high concentration in the urine.Development of resistance to metronidazole byT. vaginalishas not been demonstrated eitherin vivoorin vitro.No toxic effect was demonstrated in the blood, liver, or kidney.