Association of limbic system-associated membrane protein (LSAMP) to male completed suicide
Open Access
- 23 April 2008
- journal article
- Published by Springer Nature in BMC Medical Genetics
- Vol. 9 (1) , 34
- https://doi.org/10.1186/1471-2350-9-34
Abstract
Neuroimaging studies have demonstrated volumetric abnormalities in limbic structures of suicide victims. The morphological changes might be caused by some inherited neurodevelopmental defect, such as failure to form proper axonal connections due to genetically determined dysfunction of neurite guidance molecules. Limbic system-associated membrane protein (LSAMP) is a neuronal adhesive molecule, preferentially expressed in developing limbic system neuronal dendrites and somata. Some evidence for the association between LSAMP gene and behavior has come from both animal as well as human studies but further investigation is required. In current study, polymorphic loci in human LSAMP gene were examined in order to reveal any associations between genetic variation in LSAMP and suicidal behaviour.Keywords
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