Studies in carbohydrate metabolism

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Abstract
When dihydroxyacetone is administered intravenously to decerebrated cats from which the pancreas has been removed, the change in muscle-glycogen depends largely upon the amount of triose administered. With small quantities an increase tends to occur, with large quantities a decrease. When dextrose is administered under similar conditions, results of an analogous type are obtained, although, in this case, the relation between the amount of glucose administered and the change in glycogen may not be so great. The level of the initial blood-sugar, before pancrea-tectomy, appears to have some effect upon the change in muscle-glycogen, high initial blood-sugars tending to cause an increase. This is probably due to stimulation of insulin secretion by the pancreas. From the experiments, no evidence could be obtained that muscle-glycogen was more readily formed from dihydroxyacetone than from dextrose in presence of the liver.

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