THE REDUCTION OF EXPERIMENTAL POLYCYTHEMIAS BY LIVER ADMINISTRATION

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Abstract
Exptl. polycythemia was produced in 4 dogs as a chronic effect of daily treadmill running and in 7 dogs by the daily oral ingestion of 2 mgm. of C0Cl2. In spite of continued stimulation of the hematopoietic tissue, the daily feeding of 75 gm.s. of raw beef or hog liver caused a reduction in erythrocyte nos. and Hb to or below normal in the 4 exercised dogs and in 6 of the 7 Co-fed dogs. These reductions persisted throughout the periods of liver feeding, which varied from 6-28 days. Upon cessation of liver feeding, the erythrocyte nos. returned promptly to their previous polycythemic values. The daily oral administration of 5 gms. of ven-triculin, or of 22 cc. of a liver extract, to some of these dogs caused no significant reductions in erythrocyte nos., although the daily intramusc. inj. of another liver extract was quite effective.

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