Effect of Lipopolysaccharides of Gram Negative Bacilli in the Rat Litter in utero.

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Abstract
The lipopolysaccharides (LS) were given intraperitoneally in fractions of the LD50 to groups of pregnant rats in different gestation stages. The mother animals showed a slight increase in body temperature, a transitory rise in WBC, and occasionally focal necrosis of the liver. The placentas showed changes in the capillary endothelia, necrosis and hemorrhages. Fetuses and entire litters were destroyed with a peak of litter death between mid-term and the 15th g. d. Surviving fetuses were frequently stunted but malformations rare. The ratio of lethal doses of the LS for the fetuses and the LD50 to the mothers was for Brucella abortus Bang 1:2, for Salmonella typhosa 1:3, for Escherichia coli 1:10 and for Serratia marcescens 1:12 and could not be determined for a Gram positive Streptococcus. Large intragastric doses of LS of S. typhosa were nontoxic to mothers and litters. The LS of a Gram positive Streptococcus was less toxic to the mother rat and fetuses by an order of 1:100 than the LS of the Gram negative bacilli.

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