Cytotoxic Activity of Amaryllidaceae Alkaloids fromCrinum augustumandCrinum bulbispermum

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Abstract
The cytotoxic activity of five minor Amaryllidaceae alkaloids and one flavan isolated from Crinum augustum Rox and Crinum bulbispermum Milne were tested on human leukemic Molt 4 cells. Whereas the crinine-type alkaloids (6α-hydroxycrinine, powelline) and the new type augustamine did not even inhibit the growth of Molt 4 cells, the lycorine-type alkaloid (pratorinine) and the crinine-type alkaloid (6α-hydroxybuphanisine) showed a moderate cytotoxic activity and the flavan (4′-hydroxy-7-methoxyflavan) showed an important cytotoxic effect.

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