A cell-surface molecule involved in organ-specific homing of lymphocytes
- 1 July 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 304 (5921) , 30-34
- https://doi.org/10.1038/304030a0
Abstract
Lymphocytes migrate from the bloodstream by recognizing and binding to specialized endothelial cells lining the high endothelial venules (HEV) in lymph nodes and Peyer's patches. We describe here a monoclonal antibody, MEL-14, specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV, and to be required for lymphocyte homing into lymph nodes in vivo.Keywords
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