Alkali-Soluble and Insoluble Collagen in Infant, Adult and Cirrhotic Livers.

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Abstract
Concentration of hydroxyproline in the liver, as a measure of collagen, is lower in human infants than in adults, and histologically-stainable collagen and silver impregnated reticulum fibers are fewer. While in cirrhosis, total collagen concentration is 10 times greater than in infant livers, in both cirrhotic and infant livers the ratio of alkali-soluble collagen to total collagen is similar and considerably higher than in control adults. This suggests that formation of new collagen fibers, under both physiological and pathological circumstances, is associated with a relative increase of alkali-soluble collagen.

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