Effect of Estrogen Antibodies on Pregnancy in the Rat

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Abstract
Treatment of pregnant rats with small amounts of non-specific estrogen antibodies did not inhibit pregnancy but increased the percent males in the litter. Administration of specific antibodies to estradiol immediately following mating prevented pregnancy in all animals, while administration at mid-pregnancy caused only some reduction in the number of pregnant animals. Administration of specific estriol antibody had no effect following mating but caused nearly total resorption of fetuses at mid gestation.
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