THE EFFECTS ON VENOUS ENDOTHELIUM OF ALTERATIONS IN BLOOD FLOW THROUGH THE VESSELS IN VEIN WALLS, AND THE POSSIBLE RELATION TO THROMBOSIS

Publisher Website
Google Scholar
Abstract
A new approach is introduced to the problem of thrombosis which involves the factor of the circulation of vein walls. The present paper deals with the alterations in the endothelium coating of the veins and some of the physiologic relationships of the vein walls. Using veins of dogs, a new technic is described for the use of AgNO3 soln. in staining and studying the inner coats of the vein walls. A description is given of a special apparatus which is used to hold the vein segments while being stained, dehydrated, and cleared. By using a benzidine staining technic, the red blood cells are selectively stained an amber to dark brown color, and thereby outline the vessel in which they are contained. Applying these technics a detailed account is given on the observations of changes in the inner coats of vein walls following isolation and obstruction of vein segments. A discussion is also presented on the theoretic connections between anatomy and physiology of vasa venarum, alterations in endothelium, and clinical venous thrombotic lesions.