SUITABILITY OF RADIOPHARMACEUTICALS FOR DETERMINING RIGHT-TO-LEFT SHUNTING - CONCISE COMMUNICATION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (3) , 255-257
Abstract
Right-to-left shunting in noncyanotic patients was quantitated following the injection of either 99mTc-microspheres, 99mTc-macroaggregated albumin or 113mIn-Fe(OH)3 particles. Shunting was determined by whole-body scanning followed by estimation of the nuclide fraction located in the systemic circulation. Both 99mTc-labeled radiopharmaceuticals yielded results consistent with normal pulmonary shunting in a noncyanotic patient; 113mIn-Fe(OH)3 was less satisfactory. If the onset of scanning was delayed, the calculated shunt can be falsely elevated as the pulmonary particles fragment and pass onward or as the label is released. Proper choice of radiopharmaceutical and prompt scanning are crucial for accurate quantitation of right-to-left shunting.

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