Negative Inotropic Effect of the Vagus Nerves upon the Canine Ventricle
- 5 June 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 144 (3623) , 1223-1225
- https://doi.org/10.1126/science.144.3623.1223
Abstract
In an innervated, paced, left heart preparation in which the left ventricle contracted against a constant volume of incompressible fluid (isovolumetric preparation), electrical stimulation of the distal end of either sectioned cervical vagus nerve decreased the peak tension generated by the teft ventricle. The vagi, therefore, exert a negative inotropic effect directly upon the ventricular myocardium.Keywords
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