Heavy-particle therapy in acromegaly and Cushing disease

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Abstract
A total of 349 patients with pituitary tumors, including acromegaly, Cushing disease, Nelson syndrome, prolactin-secreting adenoma and chromophobe adenoma, were treated with heavy particle radiation during the past 17 yr. The incidence of side effects was low. Only 30 patients (8.6%) died, most of preexisting cardiovascular complications. Heavy particle therapy provides a form of treatment with no mortality and extremely low morbidity, and its use in treating pituitary disorders resulted in dramatic improvement in the signs and symptoms of patients with acromegaly and Cushing disease.

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