HEMOSTATIC CHANGES RELATED TO EXTRACORPOREAL-CIRCULATION (ECC)

  • 1 January 1981
    • journal article
    • research article
    • Vol. 30  (2) , 64-70
Abstract
After-bleeding not due to surgery following extracorporeal circulation (ECC) in open heart surgery has its origin in disorders of platelet number and function and in changes of the hemostatic balance. Not only are the plasmatic factors of the coagulation and the fibrinolytic system of importance but their inhibitors tend to avoid dysfunctions and overshooting reactions. To detect early the danger of an excessive bleeding tendency, assays of fibrinogen (factor I), prothrombin (factor II), antithrombin III (AT III) and of .alpha. 2-macroglobulin are recommended. A substitution therapy can be oriented by the results of these coagulation parameters.