A report on the side effects of ambilhar (Niridazole) and the effect of antihistamines and aspirin on these reactions

Publisher Website
Google Scholar
Abstract
The side effects of Ambilhar in 139 patients are classified according to type, system affected, severity, age, weight and dosage. Children and adolescents tolerated the drug much better than adults even when given a much higher dose relative to weight. Minor side effects were common in all age groups. One major side effect warranting the termination of treatment occurred in only 1 of 93 children and adolescents, whereas major side effects (convulsions, psychoses, a heart block and a severe epistaxis) occurred in 6 to 46 adults. All these reactions were reversible on cessation of treatment. There was no appreciable difference between the side effects of Ambilhar when given alone or in conjunction with an antihistamine. The addition of aspirin to Ambilhar markedly reduced the incidence and severity of headaches.