The Covalent Structure of Amyloid-Related Serum Protein SAA from two Patients with Inflammatory Disease
- 1 January 1983
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 364 (2) , 1039-1046
- https://doi.org/10.1515/bchm2.1983.364.2.1039
Abstract
The complete covalent structure of an amyloid-related serum protein SAA from a patient with severe rheumatoid arthritis is presented. The structure was elucidated by N-terminal analyses of the protein as well as on peptides derived from tryptic digestion and after cleaving the protein with BNPS[3-bromo-3-methyl-2-(2-nitrophenylthio-3H-indole)]-skatole. The characterization of tryptic peptide T-9 revealed a polymorphism similar to that seen in protein AA. Structural studies performed on another protein SAA, isolated from a patient with acute systemic lupus erythematosus, indicated that this protein is homologous to that from the rheumatoid arthritis patient. The formation and deposition of the protein AA-containing amyloid fibrils is discussed.This publication has 20 references indexed in Scilit:
- Isolation and characterization of the amyloid-related apoprotein (SAA) from human high density lipoprotein.Proceedings of the National Academy of Sciences, 1980
- Heterogeneity of human serum amyloid A proteins.The Journal of Experimental Medicine, 1980
- Amyloid protein SAA is an apoprotein of mouse plasma high density lipoprotein.Proceedings of the National Academy of Sciences, 1979
- Degradation of serum amyloid A protein by surface-associated enzymes of human blood monocytes.The Journal of Experimental Medicine, 1978
- Changes in Human Serum Amyloid A and C-Reactive Protein after Etiocholanolone-Induced InflammationJournal of Clinical Investigation, 1978
- Amyloid protein SAA is associated with high density lipoprotein from human serum.Proceedings of the National Academy of Sciences, 1977
- The complete amino acid sequence of an amyloid fibril protein AA1 of unusual size (64 residues)Biochemical and Biophysical Research Communications, 1976
- A Serum Component Related to Nonimmunoglobulin Amyloid Protein AS, a Possible Precursor of the FibrilsJournal of Clinical Investigation, 1974
- Evolution and the Distribution of Glutaminyl and Asparaginyl Residues in ProteinsProceedings of the National Academy of Sciences, 1974
- IMMUNOLOGIC STUDIES OF THE MAJOR NONIMMUNOGLOBULIN PROTEIN OF AMYLOIDThe Journal of Experimental Medicine, 1973