Inhibition of Platelet Aggregation by Contrast Media

Publisher Website
Google Scholar
Abstract
The effect of 30% Urografin on platelet aggregation induced by ADP, epinephrine and arachidonic acid was examined. In vivo and in vitro experiments in 10 nondiabetic subjects and in vitro experiments in 7 diabetic-uremic patients showed a statistically significant decrease in platelet aggregation 20 min after in vitro incubation or in vivo infusion with Urografin. Urografin concentration was .apprx. 2.4-2.5%. The possibility of bleeding induced by contrast media and the connection with acute renal failure in diabetic-uremic patients are discussed.