Role of C282Y mutation in haemochromatosis gene in development of type 2 diabetes in healthy men: prospective cohort study

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Abstract
We conducted a population based, prospective, four year follow up study of men aged 54 or 60 in the Kuopio ischaemic heart disease risk factor study, a population study in eastern Finland.4 Of 633 eligible men, 555 (88%) participated in the four year follow up. Of these, 508 were not diabetic (fasting blood glucose concentration ≥6.7 mmol/l and no treatment for diabetes)at baseline. A participant was defined diabetic at the end of the follow up if he had a fasting blood glucose concentration≥6.7 mmol/l, a blood glucose concentration of ≥10.0 mmol/l two hours after a glucose load, or clinical diagnosis of diabetes requiring dietary, oral, or insulin treatment.