Although John Bostock,1in 1819, first described the symptom complex of hay-fever, it was not until 1873 that Blackley2determined the real cause of the symptoms, namely, the pollen of plants. Curtis,3in 1900, was the first to attempt to produce active immunity or to treat the condition; he used extracts of the whole plant. Since Dunbar,4in 1905, was the first to employ extracts of the plant pollen, the modern treatment of hay-fever was really begun by him. During the past ten years reports on the treatment of hay-fever have been too numerous to justify reference to all of them in this paper, but the work of Noon, Freeman, Koessler, Cooke, Scheppegrell, Goodale, Selfridge and possibly of others justify the mention of their names since it is these who have done most toward establishing the treatment of seasonal hay-fever. Notwithstanding the number of papers on the subject, there is