Biotransformation oftrans-sobrerol. III. Metabolites of 8-hydroxycarvotanacetone in the rat
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 16 (4) , 317-323
- https://doi.org/10.3109/00498258609043534
Abstract
1. The metabolism of 8-hydroxycarvotanacetone (HCA), a major metabolite of trans-sobrerol, was studied in female rats after a single oral dose. 2. The metabolic pathways include hydroxylation, reduction to cis- and trans-sobrerol, glucuronylation and Michael addition with glutathione giving rise to mercapturic acids which then undergo reduction. 3. Biological reduction appears to occur more readily for the alicyclic-saturated ketones (Michael adducts) than for the α, β unsaturated ketones (HCA and hydroxylated metabolites). This is in agreement with the chemical reactivity of the compounds.This publication has 12 references indexed in Scilit:
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