The Effect of Spironolactone on Transport of Na+., K+and H+. A Microperfusion Study in Rat Main Submaxillary Duct
- 1 February 1976
- journal article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 6 (1) , 17-20
- https://doi.org/10.1111/j.1365-2362.1976.tb00488.x
Abstract
The epithelium of the main excretory duct of the rat submaxillary gland was used as a target tissue for studies on the effect of a spironolactone on electrolyte transport. The spironolactone decreased net Na+ reabsorption by 27% and net K+ secretion by 23%. HCO-3 was found to be about 2-fold accumulated in the duct lumen, which was considered to result from decreased H+ion secretion. The results can be reconciled with an action of spironolactone on 1) the peritubular Na+-K+-exchange mechanism and 2) the functional coupling of Na+ entry from lumen to cell with K+ and H+ transfer from cell to lumen.Keywords
This publication has 24 references indexed in Scilit:
- The action of aldosterone on Na+ and K+ transport in the rat submaxillary main ductPflügers Archiv - European Journal of Physiology, 1973
- Mechanism of action of aldosterone on potassium transfer in the rat kidneyPflügers Archiv - European Journal of Physiology, 1973
- Effect of aldosterone on sodium and potassium transport in the kidneyJournal of Steroid Biochemistry, 1972
- Einfluß von Aldosteron auf den Natriumtransport in den Sammelrohren der SäugetiernierePflügers Archiv - European Journal of Physiology, 1969
- Transport of sodium and secretion of potassium and bicarbonate by the colon of normal and sodium‐depleted ratsThe Journal of Physiology, 1967
- Mechanism of action of aldosteronePhysiological Reviews, 1966
- Hemmung der Natriumresorption im proximalen und distalen Konvolut adrenalektomierter RattenPflügers Archiv - European Journal of Physiology, 1966
- THE EFFECT OF ALDOSTERONE, CORTISOL, AND CORTICOSTERONE UPON THE SODIUM AND POTASSIUM CONTENT OF SHEEP'S PAROTID SALIVA*Journal of Clinical Investigation, 1963
- A COMPARATIVE STUDY OF ALDOSTERONE AND OTHER ADRENAL STEROIDS IN ADRENALECTOMIZED DOGS1Endocrinology, 1954
- INTESTINAL ABSORPTION IN THE ADRENALECTOMIZED DOGAmerican Journal of Physiology-Legacy Content, 1940