The Relationship in Mice of Intestinal Emptying Time and Natural Resistance to Hymenolepis

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Abstract
A series of expts. was carried out in young mice to show the relationship of intestinal emptying time and natural resistance to H. nana var. fraterna. In 6 of 8 expts. using various doses of opium prior to infection, the exptl. mice, as compared with controls showed both a decreased intestinal emptying time and an increased % development of cysticercoids. The same was found later in 3 of 4 expts. using morphine sulfate. Since it was suggested that these higher percentages resulted from delayed passage of the eggs, it was interesting that in the 3 expts. in which the drugged mice showed little or no increase in the % development of cysticercoids as compared with controls, there was likewise little decrease in intestinal emptying time. The presence or absence of food in the stomach of drugged mice had no apparent effect on intestinal emptying time or on the rate of development of Hymenolepis. These results tend to show that in young mice, the factor of rapid intestinal emptying time is involved in the strong natural resistance to Hymenolepis.

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