REPAIR SYNTHESIS OF DNA AFTER IRRADIATION AND ITS MODIFICATION DUE TO RADIOPROTECTION INVIVO

  • 1 January 1976
    • journal article
    • research article
    • Vol. 22  (3) , 196-+
Abstract
Repair DNA synthesis was examined in [chinese hamster Cricetulus griseus] bone marrow cells exposed to LD 50/30 in vivo. Intensive repair synthesis took place during the irradiation, and the increase in 3HTdR [tritiated thymidine] uptake prevailed over the inhibitory effect of radiation and AET [aminoethylisothiouroniumbromide hydrobromide] upon DNA synthesis. After LD 50/30, the intensity of DNA repair was reduced. Application of AET resulted in an increase in repair DNA synthesis after irradiation, indicated by a significantly higher incorporation of 3HTdR.

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