Effects of lidocaine in rabbit atria
- 1 April 1978
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 56 (2) , 175-179
- https://doi.org/10.1139/y78-024
Abstract
Standard microelectrode recordings were obtained from rabbit right and left atria. Lidocaine (1 × 10−5 M) had no effect on these, but 5 × 10−5 M lidocaine significantly slowed rate and Vmax. This concentration had no effect on the duration of the action potential, a result clearly different from the effect of this drug in Purkinje tissue. Lidocaine had much less effect on the 'steady-state' relation of membrane potential to Vmax of phase 0 of the action potential than on the 'membrane responsiveness curve obtained by the extra stimulus technique. We have demonstrated time-related recovery from sodium inactivation in rabbit left atria and have shown that lidocaine slows recovery in this tissue as it does in Purkinje fibres.This publication has 1 reference indexed in Scilit:
- THE EFFECTS ON CARDIAC MUSCLE OF β‐RECEPTOR ANTAGONISTS IN RELATION TO THEIR ACTIVITY AS LOCAL ANAESTHETICSBritish Journal of Pharmacology and Chemotherapy, 1965